msna moesin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: msnaprovided by ZNC
Official Full Name: moesin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-021211-2
See related: Ensembl:ENSDARG00000058128 AllianceGenome:ZFIN:ZDB-GENE-021211-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rdx; cb567; zgc:85640; wu:fb14b03
Summary: Predicted to enable actin binding activity and cell adhesion molecule binding activity. Acts upstream of or within blood vessel lumenization and endoderm development. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Predicted to be active in several cellular components, including adherens junction; filopodium; and microvillus. Is expressed in several structures, including cardiovascular system; gut; hypochord; nervous system; and swim bladder bud. Human ortholog(s) of this gene implicated in immunodeficiency 50. Orthologous to human MSN (moesin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (22133375..22174040)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (21629575..21670237)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

suggest that Ve-cadherin and Moesin1 function to establish and maintain apical/basal polarity during multicellular lumen formation in the intersegmental vessels
Title: Moesin1 and Ve-cadherin are required in endothelial cells during in vivo tubulogenesis.
results suggest a new role for moesin, acting in a signalling pathway facilitating the differentiation of extraembryonic endoderm
Title: Moesin signalling induces F9 teratocarcinoma cells to differentiate into primitive extraembryonic endoderm.

Submit: New GeneRIF Correction

General gene information

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Markers

fj89b04.x1 (e-PCR)
- UniSTS:200235

fa97e01.x1 (e-PCR)
- UniSTS:189744

AI385017 (e-PCR)
- UniSTS:206701

fd04h03.y1 (e-PCR)
- UniSTS:194937

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel lumenization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endoderm development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein localization to early endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of organelle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: moesin a; moesin

Names: moesin1; msn1; radixin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004296.1 → NP_001004296.1 moesin a

See identical proteins and their annotated locations for NP_001004296.1

Status: PROVISIONAL

Source sequence(s)

BC081551

UniProtKB/TrEMBL

A0A8M1N247, A2CF04, Q66I42

Related

ENSDARP00000017246.8, ENSDART00000016214.9

Conserved Domains (5) summary

smart00295
Location:7 → 206

B41; Band 4.1 homologues

cd13194
Location:200 → 296

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:91 → 206

FERM_M; FERM central domain

pfam00769
Location:347 → 579

ERM; Ezrin/radixin/moesin family

pfam09379
Location:9 → 71

FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

22133375..22174040

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301281.3 → XP_009299556.1 moesin isoform X1

UniProtKB/TrEMBL

A0A8M3B2A2

Conserved Domains (5) summary

smart00295
Location:1 → 195

B41; Band 4.1 homologues

cd13194
Location:189 → 285

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:80 → 195

FERM_M; FERM central domain

pfam00769
Location:336 → 568

ERM; Ezrin/radixin/moesin family

pfam09379
Location:2 → 60

FERM_N; FERM N-terminal domain
XM_009301282.3 → XP_009299557.1 moesin isoform X2

UniProtKB/TrEMBL

A0A8M3AZE1

Conserved Domains (3) summary

cd13194
Location:64 → 160

FERM_C_ERM; FERM domain C-lobe/F3 of the ERM family

pfam00373
Location:24 → 70

FERM_M; FERM central domain

pfam00769
Location:211 → 443

ERM; Ezrin/radixin/moesin family